Main

James Cranley

BM BCh, MA, MRCP

I am an academic cardiology trainee. My clinical interest lies at the intersect of inherited cardiac conditions and electrophysiology. I am currently pursuing a PhD fellowship at the Sanger Institute in the lab of Dr Sarah Teichmann. I am using cutting edge single-cell and spatial transcriptomic methods to create a next-generation cell atlas of the human heart.

Education

Sanger Institute (University of Cambridge)

PhD at Teichmann Lab

Cambridge, UK

2024 - 2021

Cambridge University

PG Certificate in Medical Education

Cambridge, UK

2019

Academic Clinical Fellowship in Cardiology

National Instiute for Health Research (NIHR)
3 month research fellowships in:

N/A

2018 - 2015

Huang Lab, Cambridge Unversity
MacRae Lab, Harvard Unversity
Munroe Lab, Queen Mary University of London

Membership of the Royal College of Physicians

Royal College of Physicians

London, UK

2016

Oxford Medical School

BM BCh (Distinction)
Intercalated BA in Medical Science (1st class)
Academic (“Old Members’”) scholarship

Oxford, UK

2013 - 2007

Eton College

Academic (“Oppidan”) scholarship
7 ’A’s (Maths, Further Maths, Chemistry, Biology, French, Latin, Greek)

Windsor, UK

2007 - 2002

Research Experience

Wellcome Trust PhD Fellowship

N/A

Sanger Institute

2024 - 2021

Single cell and spatial transcriptomic analysis of the adult and developing human heart
50% wet lab genomics (single-cell and spatial transcriptomic)
50% bioinformatics (python, Bash, R)

NIHR Academic Clinical Fellowship

2018: Genome-wide association study into ECG trait using UK Biobank data. Supervisor: Prof Patsy Munroe/QMUL.
2017: Introduction to zebrafish as a model for cardiovascular disease. Supervisor: Prof Calum MacRae/Harvard University
2016: A murine model of metabolic syndrome. Supervisor: Prof Chris Huang/Cambridge University.

N/A

2018 - 2016

Bachelor’s of Science (intercalated)

Investigating the role of the neuropeptide Galanin in cardiac autonomics using a guinea pig Langendorff model. Supervisor: Prof Neil Herring/Oxford University

Oxford University

2013

Clinical Experience

Specialty Training, Cardiology

N/A

East of England deanery

current - 2017

ST6: Royal Papworth Hospital
ST5: Norfolk & Norwich Hospital
ST3 & ST4: Addenbrooke’s Hospital

Core Medical Training

N/A

East of England deanery

2017 - 2015

Papworth Hospital: Cardiology
Hinchingbrooke Hospital: Respiratory
Addenbrooke’s Hospital: ICU

Foundation Training

N/A

North West Thames deanery

2015 - 2013

Harefield Hospital: Cardiology
Hillingdon Hospital: A&E
Charing Cross Hospital: Acute Medicine

Medical Elective

N/A

Mount Sinai Hospital, New York

2013

Cardiology Dept, Mount Sinai Hospital. Supervisor: Dr Valentin Fuster

Teaching Experience

BJCA Trainee Representative to BHRS

Committe role representing electrophysiology trainees nationally.

N/A

current - 2022

Adult Life Support Instructor

Registered provider and instructor

N/A

current - 2020

Cardiology Webinars

Organised and recorded a series of educational webinars for cardiology trainees, now hosted at BJCA.tv

N/A

2021 - 2020

Trainee Representative for East of England

Designed and delivered training days, created website.

N/A

2020 - 2017

Preclinical (physiology) and clinical supervisor

Gonville & Caius College, Cambridge

N/A

2017 - 2016

Harefield Medical Student Teaching Programme

Organised a fortnightly schedule for rotating medical students. Taught regularly.

N/A

2015 - 2014

ECG Course - Oxford Revision Courses

Oxford Medical School

N/A

2015

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Publications

A single-cell comparison of adult and fetal human epicardium defines the age-associated changes in epicardial activity

Nature Cardiovascular Research
Vincent R. Knight-Schrijver, Hongorzul Davaapil, Semih Bayraktar, Alexander D. B. Ross, Kazumasa Kanemaru, James Cranley, Monika Dabrowska, Minal Patel, Krzysztof Polanski, Xiaoling He, Ludovic Vallier, Sarah Teichmann, Laure Gambardella, Sanjay Sinha

N/A

2022

Single-cell transcriptomics for the assessment of cardiac disease

Nature Reviews Cardiology
Antonio M. A. Miranda, Vaibhao Janbandhu, Henrike Maatz, Kazumasa Kanemaru, James Cranley, Sarah A. Teichmann, Norbert Hübner, Michael D. Schneider, Richard P. Harvey, Michela Noseda

N/A

2022

Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies

Science
Daniel Reichart, Eric L. Lindberg, Henrike Maatz, Antonio M. A. Miranda, Anissa Viveiros, Nikolay Shvetsov, Anna Gärtner, Emily R. Nadelmann, Michael Lee, Kazumasa Kanemaru, Jorge Ruiz-Orera, Viktoria Strohmenger, Daniel M. DeLaughter, Giannino Patone, Hao Zhang, Andrew Woehler, Christoph Lippert, Yuri Kim, Eleonora Adami, Joshua M. Gorham, Sam N. Barnett, Kemar Brown, Rachel J. Buchan, Rasheda A. Chowdhury, Chrystalla Constantinou, James Cranley, Leanne E. Felkin, Henrik Fox, Ahla Ghauri, Jan Gummert, Masatoshi Kanda, Ruoyan Li, Lukas Mach, Barbara McDonough, Sara Samari, Farnoush Shahriaran, Clarence Yapp, Caroline Stanasiuk, Pantazis I. Theotokis, Fabian J. Theis, Antoon van den Bogaerdt, Hiroko Wakimoto, James S. Ware, Catherine L. Worth, Paul J. R. Barton, Young-Ae Lee, Sarah A. Teichmann, Hendrik Milting, Michela Noseda, Gavin Y. Oudit, Matthias Heinig, Jonathan G. Seidman, Norbert Hubner, Christine E. Seidman

N/A

2022

Impact of COVID-19 pandemic on cardiac rhythm management services: Views from the United Kingdom.

Heart rhythm O2
Wern Yew Ding, James Cranley, David Begley, Archana Rao, Richard L. Snowdon, Greg Mellor, Dhiraj Gupta

N/A

2022

Identifying predictive risk factors for permanent pacemaker implantation up to 30 days post-TAVI

European Heart Journal
J Li, A Christodoulidou, James Cranley, F Ara, Charis Costopoulos, P Costanzo, M Osullivan, W Davies, C Densem, C A Martin

N/A

2021

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction.

Nature communications
Ioanna Ntalla, Lu-Chen Weng, James H. Cartwright, Amelia Weber Hall, Gardar Sveinbjornsson, Nathan R. Tucker, Seung Hoan Choi, Mark D. Chaffin, Carolina Roselli, Michael R. Barnes, Borbala Mifsud, Helen R. Warren, Caroline Hayward, Jonathan Marten, James Cranley, Pier D. Lambiase, Michele Orini, Julia Ramirez, Stefan Van Duijvenboden, David O. Arnar, Daniel F. Gudbjartsson, Hilma Holm, Patrick Sulem, Gudmar Thorleifsson, Rosa B. Thorolfsdottir, Unnur Thorsteinsdottir, Emelia J. Benjamin, Andrew Tinker, Kari Stefansson, Patrick T. Ellinor, Yalda Jamshidi, Steven A. Lubitz, Patricia B. Munroe

N/A

2020

Pulsed Levosimendan in advanced heart failure due to congenital heart disease: a case series.

European heart journal. Case reports
James Cranley, Antonia Hardiman, Leisa J Freeman

N/A

2020

Clinical outcomes of bioresorbable vascular scaffolds implanted with routine versus selective optical coherence tomography guidance: results from a single-centre experience.

EuroIntervention
Vincent Floré, Adam J. Brown, Joel P. Giblett, Kevin Liou, James Cranley, Stephen P. Hoole, Nick E.J. West

N/A

2019

Catastrophic antiphospholipid syndrome causing ST-segment elevation myocardial infarction with non-obstructive coronary arteries.

BMJ case reports
James Cranley, Unni Krishnan, Katharine Tweed, Rudolf Martin Duehmke

N/A

2019

Regulatory and occupational considerations in cardiology

Medicine
James Cranley, Catriona Bhagra

N/A

2018

Ventricular pro-arrhythmic phenotype, arrhythmic substrate, ageing and mitochondrial dysfunction in peroxisome proliferator activated receptor-γ coactivator-1β deficient (Pgc-1β^-/-) murine hearts.

Mechanisms of ageing and development
Shiraz Ahmad, Haseeb Valli, Karan R. Chadda, James Cranley, Kamalan Jeevaratnam, Christopher L.-H. Huang

N/A

2018

A New Approach to an Old Problem: One Brave Idea.

Circulation research
James Cranley, Calum A. MacRae

N/A

2018

TCT-405 Optical coherence tomography-guided optimal bioresorbable vascular scaffold implantation informs subsequent implantation without intravascular imaging: further evidence for a ‘learning curve’?

Journal of the American College of Cardiology
Vincent Floré, Adam Brown, James Cranley, Joel Giblett, Stephen Hoole, Nick West

N/A

2016

Long-term follow-up of patients undergoing free tissue transfer to the lower limb following trauma

European Journal of Plastic Surgery
Dipender Gill, David J. Bruce, Mark J. Ponsford, James Cranley, Timothy E. Goodacre

N/A

2013

The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: implications for neural control of cardiac excitability.

Journal of molecular and cellular cardiology
Neil Herring, James Cranley, Michael N. Lokale, Dan Li, Julia Shanks, Eric N. Alston, Beatrice M. Girard, Emma Carter, Rodney L. Parsons, Beth A. Habecker, David J. Paterson

N/A

2011

Galanin reduces cardiac vagal acetylcholine release and bradycardia via a GalR1, protein kinase C dependent pathway

The FASEB Journal
Neil Herring, James Cranley, Michael N Lokale, Beth Habecker, David J Paterson

N/A

2010

Aside

Contact

Disclaimer

Main

James Cranley

Education

Sanger Institute (University of Cambridge)

Cambridge University

Academic Clinical Fellowship in Cardiology

Membership of the Royal College of Physicians

Oxford Medical School

Eton College

Research Experience

Wellcome Trust PhD Fellowship

NIHR Academic Clinical Fellowship

Bachelor’s of Science (intercalated)

Clinical Experience

Specialty Training, Cardiology

Core Medical Training

Foundation Training

Medical Elective

Teaching Experience

BJCA Trainee Representative to BHRS

Adult Life Support Instructor

Cardiology Webinars

Trainee Representative for East of England

Preclinical (physiology) and clinical supervisor

Harefield Medical Student Teaching Programme

ECG Course - Oxford Revision Courses

Publications

A single-cell comparison of adult and fetal human epicardium defines the age-associated changes in epicardial activity

Single-cell transcriptomics for the assessment of cardiac disease

Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies

Impact of COVID-19 pandemic on cardiac rhythm management services: Views from the United Kingdom.

Identifying predictive risk factors for permanent pacemaker implantation up to 30 days post-TAVI

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction.

Pulsed Levosimendan in advanced heart failure due to congenital heart disease: a case series.

Clinical outcomes of bioresorbable vascular scaffolds implanted with routine versus selective optical coherence tomography guidance: results from a single-centre experience.

Catastrophic antiphospholipid syndrome causing ST-segment elevation myocardial infarction with non-obstructive coronary arteries.

Regulatory and occupational considerations in cardiology

Ventricular pro-arrhythmic phenotype, arrhythmic substrate, ageing and mitochondrial dysfunction in peroxisome proliferator activated receptor-γ coactivator-1β deficient (Pgc-1β-/-) murine hearts.

A New Approach to an Old Problem: One Brave Idea.

TCT-405 Optical coherence tomography-guided optimal bioresorbable vascular scaffold implantation informs subsequent implantation without intravascular imaging: further evidence for a ‘learning curve’?

Long-term follow-up of patients undergoing free tissue transfer to the lower limb following trauma

The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: implications for neural control of cardiac excitability.

Galanin reduces cardiac vagal acetylcholine release and bradycardia via a GalR1, protein kinase C dependent pathway

Ventricular pro-arrhythmic phenotype, arrhythmic substrate, ageing and mitochondrial dysfunction in peroxisome proliferator activated receptor-γ coactivator-1β deficient (Pgc-1β^-/-) murine hearts.